Last data update: May 06, 2024. (Total: 46732 publications since 2009)
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Query Trace: Castro-Arellano I[original query] |
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Seroprevalence, risk factors, and rodent reservoirs of leptospirosis in an urban community of Puerto Rico, 2015
Briskin EA , Casanovas-Massana A , Ryff KR , Morales-Estrada S , Hamond C , Perez-Rodriguez NM , Benavidez KM , Weinberger DM , Castro-Arellano I , Wunder EA , Sharp TM , Rivera-Garcia B , Ko AI . J Infect Dis 2019 220 (9) 1489-1497 BACKGROUND: The burden of leptospirosis in Puerto Rico remains unclear due to underreporting. METHODS: A cross-sectional survey and rodent trapping was performed in a community within San Juan, Puerto Rico to determine the seroprevalence and risk factors for Leptospira infection. The microscopic agglutination test was used to detect anti-Leptospira antibodies as a marker of previous infection. We evaluated Leptospira carriage by qPCR among rodents trapped at the community site. RESULTS: Of 202 study participants, 55 (27.2%) had Leptospira agglutinating antibodies. Among the 55 seropositive individuals, antibodies were directed most frequently against serogroups Icterohaemorrhagiae (22.0%) and Autumnalis (10.6%). Of 18 captured rodents, 11 (61.1%) carried pathogenic Leptospira (L. borgpetersenii, 7 and L. interrogans, 2). Four participants showed their highest titer against an isolate obtained from a rodent (serogroup Ballum). Increasing household distance to the canal that runs through the community was associated with decreased risk of infection (OR = 0.934 per 10m increase, 95% CI: 0.952-0.992). CONCLUSION: There are high levels of Leptospira exposure in an urban setting in Puerto Rico, for which rodents may be an important reservoir for transmission. Our findings indicate that prevention should focus on mitigating risk posed by infrastructure deficiencies such as the canal. |
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